Chresta, C. M.: search on Z-Library

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1

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Guichard, S. M., Curwen, J., Bihani, T., D'Cruz, C. M., Yates, J. W. T., Grondine, M., Howard, Z., Davies, B. R., Bigley, G., Klinowska, T., Pike, K. G., Pass, M., Chresta, C. M., Polanska, U. M., McE

Journal:

Molecular Cancer Therapeutics

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

2

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

Chresta, C. M., Davies, B. R., Hickson, I., Harding, T., Cosulich, S., Critchlow, S. E., Vincent, J. P., Ellston, R., Jones, D., Sini, P., James, D., Howard, Z., Dudley, P., Hughes, G., Smith, L., Mag

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 932 KB

english, 2010

3

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

Roepman, Paul, Schlicker, Andreas, Tabernero, Josep, Majewski, Ian, Tian, Sun, Moreno, Victor, Snel, Mireille H, Chresta, Christine M, Rosenberg, Robert, Nitsche, Ulrich, Macarulla, Teresa, Capella, G

Journal:

International Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 1.78 MB

english, 2014

4

Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background

Davies, B. R., Greenwood, H., Dudley, P., Crafter, C., Yu, D.-H., Zhang, J., Li, J., Gao, B., Ji, Q., Maynard, J., Ricketts, S.-A., Cross, D., Cosulich, S., Chresta, C. C., Page, K., Yates, J., Lane,

Journal:

Molecular Cancer Therapeutics

Year:

2012

Language:

english

File:

PDF, 871 KB

english, 2012

5

Apoptosis: its relevance to carcinogenesis and anti-tumour drug sensitivity

Christine M. Chresta, John A. Hickman

Journal:

Year:

1999

Language:

english

File:

PDF, 50 KB

english, 1999

6

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

Arriola, Emma L, Lopez, Ana Rodriguez, Chresta, Christine M

Journal:

Year:

1999

Language:

english

File:

PDF, 387 KB

english, 1999

7

Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells

Sini, Patrizia, James, Dominic, Chresta, Christine, Guichard, Sylvie

Journal:

Year:

2010

Language:

english

File:

PDF, 264 KB

english, 2010

8

Progesterone receptor antagonists are potential inhibitors of breast cancer stem cell activity

Alferez, D., Eyre, R., Spence, K., Hayhurst, W., Chresta, C., Sacha, H., Clarke, R.

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 60 KB

english, 2016

9

Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells

Rachel S. Chapman, Christine M. Chresta, Ali Alejo Herberg, Helen M. Beere, Sukhbindar Heer, Anthony D. Whetton, John A. Hickman, Caroline Dive

Journal:

Cytometry Part A

Year:

1995

Language:

english

File:

PDF, 1.10 MB

english, 1995

10

Potentiation of etoposide-induced cytotoxicity and DNA damage in CCRF-CEM cells by pretreatment with non-cytotoxic concentrations of arabinosyl cytosine

Christine M. Chresta, Raymond Hicks, John A. Hartley, Robert L. Souhami

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1992

Language:

english

File:

PDF, 894 KB

english, 1992

11

Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

Arriola, Emma L, Rodriguez-Lopez, Ana M, Hickman, John A, Chresta, Christine M

Journal:

Year:

1999

Language:

english

File:

PDF, 430 KB

english, 1999

12

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Winter, Jon J. G., Anderson, Malcolm, Blades, Kevin, Brassington, Claire, Breeze, Alexander L., Chresta, Christine, Embrey, Kevin, Fairley, Gary, Faulder, Paul, Finlay, M. Raymond V., Kettle, Jason G.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 9.61 MB

english, 2015

13

Enhanced MAPK signaling drives ETS1-mediated induction of miR-29b leading to downregulation of TET1 and changes in epigenetic modifications in a subset of lung SCC

Taylor, M A, Wappett, M, Delpuech, O, Brown, H, Chresta, C M

Journal:

Year:

2016

Language:

english

File:

PDF, 3.85 MB

english, 2016

14

Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)

Dry, J. R., Pavey, S., Pratilas, C. A., Harbron, C., Runswick, S., Hodgson, D., Chresta, C., McCormack, R., Byrne, N., Cockerill, M., Graham, A., Beran, G., Cassidy, A., Haggerty, C., Brown, H., Ellis

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 973 KB

english, 2010

15

High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)

Meng, Jieru, Peng, Henry, Dai, Bingbing, Guo, Wei, Wang, Li, Ji, Lin, Minna, John D., Chresta, Christine M., Smith, Paul D., Fang, Bingliang, Roth, Jack A.

Journal:

Cancer Biology & Therapy

Year:

2009

Language:

english

File:

PDF, 2.47 MB

english, 2009

16

MDM2 Mediated Nuclear Exclusion of p53 Attenuates Etoposide-Induced Apoptosis in Neuroblastoma Cells

Rodriguez-Lopez, Ana M., Xenaki, Dia, Eden, Tim O. B., Hickman, John A., Chresta, Christine M.

Journal:

Molecular Pharmacology

Year:

2001

File:

PDF, 506 KB

2001

17

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

Andreas Schlicker, Garry Beran, Christine M Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides, Tim French

Journal:

BMC Medical Genomics

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

18

Design and campaign synthesis of pyridine-based histone deacetylase inhibitors

David M. Andrews, Keith M. Gibson, Mark A. Graham, Zbigniew S. Matusiak, Craig A. Roberts, Elaine S.E. Stokes, Madeleine C. Brady, Christine M. Chresta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

19

Oddball p53 in testicular tumors

Chresta, Christine M., Hickman, John A.

Journal:

Nature Medicine

Year:

1996

File:

PDF, 284 KB

1996

20

319 POSTER Pharmacodynamics and anti-tumour activity of KU-0063794, a potent and specific inhibitor of mTOR kinase

B.R. Davies, C.M. Chresta, P. Dudley, N. Hewitt, M. Brady, M. Jacobsen, I. Hickson, N.M.B. Martin, G.C.M. Smith, M. Pass

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

21

134. Stimulatory and inhibitory effects of DNA topoisomerase II (Topo II) inhibitors on colony formation of human bone marrow progenitor cells

Tejedor, MC, Chresta, C, Berney, J, Delgado, C, Francis, GE

Journal:

Biomedicine & Pharmacotherapy

Year:

1992

Language:

english

File:

PDF, 106 KB

english, 1992

22

MDM2 Mediated Nuclear Exclusion of p53 Attenuates Etoposide-Induced Apoptosis in Neuroblastoma Cells

Rodriguez-Lopez, Ana M., Xenaki, Dia, Eden, Tim O. B., Hickman, John A., Chresta, Christine M.

Journal:

Molecular Pharmacology

Year:

2001

Language:

english

File:

PDF, 506 KB

english, 2001

23

Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)

Holt, S. V., Logie, A., Davies, B. R., Alferez, D., Runswick, S., Fenton, S., Chresta, C. M., Gu, Y., Zhang, J., Wu, Y.-L., Wilkinson, R. W., Guichard, S. M., Smith, P. D.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 481 KB

english, 2012

24

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

García‑Martínez, Juan M., Moran, Jennifer, Clarke, Rosemary G., Gray, Alex, Cosulich, Sabina C., Chresta, Christine M., Alessi, Dario R.

Journal:

Biochemical Journal

Year:

2009

Language:

english

File:

PDF, 1.22 MB

english, 2009

25

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

David M. Andrews, Elaine S.E. Stokes, Greg R. Carr, Zbigniew S. Matusiak, Craig A. Roberts, Michael J. Waring, Madeleine C. Brady, Christine M. Chresta, Simon J. East

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 202 KB

english, 2008

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